Peer reviewed publications (since establishment of the group at the DKFZ in 2012)
2022
Dierks, S.; Thiele, K.; Bohne, W.; Lugert, R.; Weig, M.; Groß, U.; von Ahsen, N.; Schanz, J.; Fischer, A.; Schnelle, M. Comparison and Harmonization of Different Semi-Automated and Automated qRT-PCR Assays in the Assessment of SARS-CoV-2. Viruses 2022, 14, 2239. https://doi.org/10.3390/v14102239
Shahid, S.; Pantakani, M.; Binder, L.; Fischer, A.; Pantakani, K.; Asif, A.R. Small Molecule BRD4 Inhibitors Apabetalone and JQ1 Rescues Endothelial Cells Dysfunction, Protects Monolayer Integrity and Reduces Midkine Expression. Molecules 2022, 27, 7453. https://doi.org/10.3390/molecules27217453
Alsina-Sanchis E*, Mülfarth R*, Böhn S, Wiedmann L, Jordana-Urriza L, Ziegelbauer T, Zimmer E, Taylor J, De Angelis Rigotti F, Stögbauer A, Giaimo BD, Cerwenka A, Borggrefe T, Fischer A*, Rodriguez-Vita J*. Endothelial RBPJ is essential for the education of tumor-associated macrophages. Cancer Res. 2022. https://doi.org/10.1158/0008-5472.CAN-22-0076
Jarausch, J.; Neuenroth, L.; Andag, R.; Leha, A.; Fischer, A.; Asif, A.R.; Lenz, C.; Eidizadeh, A. Influence of Shear Stress, Inflammation and BRD4 Inhibition on Human Endothelial Cells: A Holistic Proteomic Approach. Cells 2022, 11, 3086. https://doi.org/10.3390/cells11193086
Hasan SS, Fischer A. Notch Signaling in the Vasculature: Angiogenesis and Angiocrine Functions. Cold Spring Harb Perspect Med. 2022. doi: 10.1101/cshperspect.a041166
Wiedmann L*, De Angelis Rigotti F*, Vaquero-Siguero N, Donato E, Espinet E, Moll I, Alsina-Sanchis E, Mülfarth R, Vacca M, Gerwing J, Trumpp A, Fischer A*, Rodriguez-Vita J*. HAPLN1 is a driver for peritoneal carcinomatosis in pancreatic cancer. bioRxiv 2022.05.30.493185; doi: https://doi.org/10.1101/2022.05.30.493185
Hollstein MM, Münsterkötter L, Schön MP, Bergmann A, Husar TM, Abratis A, Eidizadeh A, Dierks S, Schaffrinski M, Zachmann K, Schmitz A, Holsapple JS, Stanisz-Bogeski H, Schanz J, Fischer A, Groß U, Leha A, Zautner AE, Schnelle M*, Erpenbeck L*. Long-term effects of homologous and heterologous SARS-CoV-2 vaccination on humoral and cellular immune responses. Allergy. 2022 May 14. doi: 10.1111/all.15373. Online ahead of print.
Dierks S, Andag R, Gauss F, Budde K, Francke P, Peschka M, Fischer A, Schanz J, Petersmann A. Evaluation of the AFIAS-1 thyroid-stimulating hormone point of care test and comparison with laboratory-based devices. Clin Chem Lab Med. 2022 Apr 25;60(7):1031-1038. doi: 10.1515/cclm-2022-0054.
Zechmeister B, Erden T, Kreutzig B, Weber M, Joly P, Erdmann J, Brockmann-Hönig C, Fischer A, Eidizadeh A. Analytical interference of 33 different hemoglobin variants on HbA1c measurements comparing high-performance liquid chromatography with whole blood enzymatic assay: A multi-center study. Clin Chim Acta. 2022 Apr 1;531:145-151. doi: 10.1016/j.cca.2022.03.028. Online ahead of print.
Wolff G, Sakurai M, Mhamane A, Troullinaki M, Maida A, Deligiannis IK, Yin K, Weber P, Morgenstern J, Wieder A, Kwon Y, Sekar R, Zeigerer A, Roden M, Blüher M, Volk N, Poth T, Hackert T, Wiedmann L, De Angelis Rigotti F, Rodriguez-Vita J, Fischer A, Mukthavaram R, Limphong P, Tachikawa K, Karmali P, Payne J, Chivukula P, Ekim-Üstünel B, Martinez-Jimenez CP, Szendrödi J, Nawroth P, Herzig S. Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function. Mol Metab. 2022 Jun;60:101487. doi: 10.1016/j.molmet.2022.101487.
Weis EM, Puchalska P, Nelson A , Taylor J, Moll I, Hasan SS, Dewenter M, Hagenmueller M, Fleming T, Poschet G, Hotz-Wagenblatt A, Backs J, Crawford P, Fischer A. Ketone body oxidation increases cardiac endothelial cell proliferation. EMBO Mol Med. 2022. http://doi.org/10.15252/emmm.202114753
Hollstein MM, Münsterkötter L, Schön MP, Bergmann A, Husar TM, Abratis A, Eidizadeh A, Schaffrinski M, Zachmann K, Schmitz A, Holsapple JS, Stanisz-Bogeski H, Schanz J, Fischer A, Groß U, Leha A, Zautner AE, Schnelle M*, Erpenbeck L*. Interdependencies of cellular and humoral immune responses in heterologous and homologous SARS‑CoV‑2 vaccination. Allergy 2022. https://doi.org/10.1111/all.15247
2021
Laban H, Siegmund S, Zappe M, Trogisch FA, Heineke H, De La Torre C, Fisslthaler B, Arnold C, Lauryn J, Büttner M, Mogler C, Kato K, Adams RH, Kuk H, Fischer A, Hecker M, Kuebler WM, Korff T. NFAT5/TonEBP limits pulmonary vascular resistance in the hypoxic lung by controlling mitochondrial reactive oxygen species generation in arterial smooth muscle cells. Cells. 10(12), 3293; 2021. https://doi.org/10.3390/cells10123293
Kappert L, Ruzicka P, Kutikhin A, Feldner A, Sticht C, Fischer A, Hecker M, Arnold C, Korff T. Loss of Nfat5 promotes lipid accumulation in vascular smooth muscle cells. FASEB. 35(9):e21831. 2021
Fleming T, von Nettelbladt B, Morgenstern J, Campos M, Le Marois M, Bartosova M, Hausser I, Schwab C, Fischer A, Nawroth PP, Szendroedi J, Herzig S. Methylglyoxal Induces Endothelial Dysfunction via Stunning-like Phenotype. bioRxiv 2021.11.18.469085; doi: https://doi.org/10.1101/2021.11.18.469085
Alsina-Sanchis E, Mülfarth R, Fischer A. Control of Tumor Progression by Angiocrine Factors. Cancers (Basel) 13(11):2610. doi: 10.3390/cancers13112610. [cover story]
De Angelis Rigotti F*, Wiedmann L*, Hubert MO, Vacca M, Hasan SS, Moll I, Carvajal S, Jiménez W, Starostecka M, Billeter AT, Müller-Stich B, Wolff G, Ekim-Üstünel B, Herzig S, Mogler C, Fischer A*, Rodriguez-Vita J*. Semaphorin 3C exacerbates liver fibrosis. bioRxiv 2021.07.29.454292; doi: https://doi.org/10.1101/2021.07.29.454292
Alsina Sanchis E, Mülfarth R, Moll I, Mogler C, Rodriguez-Vita J*, Fischer A*: Intraperitoneal oil application causes local inflammation with depletion of resident peritoneal macrophages. Mol Cancer Res. 19(2):288-300. doi: 10.1158/1541-7786.MCR-20-0650. [cover story]
Hubert MO, Rodriguez-Vita J, Wiedmann L, Fischer A: Isolation of murine primary aortic smooth muscle cells. BioProtocol. 11(3):e3907. doi: 10.21769/BioProtoc.3907. [cover story]
Morgenstern J, Fleming T, Kliemank E, Brune M, Nawroth PP, Fischer A: Quantification of all-trans retinoic acid by liquid chromatography-tandem mass spectrometry and association with lipid profile in patients with type 2 diabetes. Metabolites. 11(1), 60; 2021.
Hasan SS, Fischer A: The endothelium: an active regulator of lipid and glucose homeostasis. Trends Cell Biol. 31(1):37-49. 2021
2020
Hasan SS, Fischer A: Notch signaling in familial cerebral cavernous malformations and immunohistochemical detection of cleaved Notch intracellular domain. Methods Mol Biol. 2152:427-435, 2020
Hasan SS*, Jabs M*, Taylor J, Wiedmann L, Leibing T, Nordström V, Federico G, Roma LP, Carlein C, Wolff G, Ekim-Üstünel B, Brune M, Moll I, Tetzlaff F, Gröne H-J, Fleming T, Géraud C, Herzig S, Nawroth PP, Fischer A: Endothelial Notch signaling controls insulin transport in muscle. EMBO Mol Med, 12(4):e09271., 2020.
2019
Taylor J, Fischer A: EC dictate cardiac fuel source. Aging, 11: 1083-4, 2019
Klose R, Prinz A, Tetzlaff F, Weis EM, Moll I, Rodriguez-Vita J, Oka C, Korff T, Fischer A: Loss of the serine protease HTRA1 impairs smooth muscle cells maturation. Sci Rep. Dec 3;9(1):18224. 2019
2018
Tetzlaff F and Fischer A: Human EC spheroid-based sprouting angiogenesis assay in collagen. BioProtocol, 8(17), 2018.
Klose R, Adam MG, Weis EM, Moll I, Wüstehube-Lausch J, Tetzlaff F, Oka C, Ehrmann M, Fischer A: Inactivation of the serine protease HTRA1 inhibits tumor growth by deregulating angiogenesis. Oncogene, 37: 4260-72, 2018.
Jabs M, Rose AJ, Lehmann LH, Taylor J, Moll I, Sijmonsma TP, Herberich SE, Sauer SW, Poschet G, Federico G, Mogler C, Weis EM, Augustin HG, Yan M, Gretz N, Schmid RM, Adams RH, Gröne HJ, Hell R, Okun JG, Backs J, Nawroth PP, Herzig S, Fischer A. (2018) Inhibition of endothelial Notch signaling impairs fatty acid transport and leads to metabolic and vascular remodeling of the adult heart. Circulation. Jun 12;137(24):2592-2608.
Tetzlaff F, Adam MG, Feldner A, Moll I, Menuchin A, Rodriguez-Vita J, Sprinzak D, Fischer A. (2018) MPDZ promotes DLL4-induced Notch signaling during angiogenesis. eLife. Apr 5;7. pii: e32860.
Tetzlaff F, Fischer A: Control of blood vessel formation by Notch signaling. Adv Exp Med Biol, 1066: 319-338, 2018.
Fischer A, Braga VMM: Vascular permeability: Flow-mediated, non-canonical notch signaling promotes barrier integrity. Curr Biol, 28: R119-R121, 2018.
Fischer A, Nawroth PP: Chapters 31, 33, 42,47 and 54 in Kihm L, Kopf S, Nawroth PP (Ed.), Diabetes-Therapie – informiert entscheiden. Patientenzentriertes und fallbasiertes Vorgehen über Leitlinien hinaus. Springer. Berlin Heidelberg. 2018
2017
Feldner A, Adam MG, Tetzlaff F, Moll I, Komljenovic D, Sahm F, Bäuerle T, Ishikawa H, Schroten H, Korff T, Hofmann I, Wolburg H, von Deimling A, Fischer A. Loss of Mpdz impairs ependymal cell integrity leading to perinatal-onset hydrocephalus in mice. EMBO Mol Med. Jul;9(7):890-905., 2017
Wieland E*, Rodriguez-Vita J*, Liebler SS, Mogler C, Moll I, Herberich SE, Espinet E, Herpel E, Menuchin A, Chang-Claude J, Hoffmeister M, Gebhardt C, Brenner H, Trumpp A, Siebel CW, Hecker M, Utikal J, Sprinzak D, Fischer A: Endothelial Notch1 activity facilitates metastasis. Cancer Cell, 3: 355-367, 2017.
Editorial in Cancer Discovery.
Rodriguez Vita J, Tetzlaff F, Fischer A (2017) Notch controls endothelial cells. Oncoscience. Jun 25;4(5-6):45-46.
Rodriguez Vita J, Fischer A (2017) Notch1 induces endothelial senescence and promotes tumor progression. Cell Cycle. May 19;16(10):911-912, 2017
Rodriguez Vita J, Fischer A (2017) Notch signaling facilitates crossing of endothelial barriers by tumor cells. Mol Cell Oncol. Apr 3;4(3):e1311828.
2016
Spiegler S, Kirchmaier B, Rath M, Korenke GC, Tetzlaff F, van de Vorst M, Neveling K, Acker-Palmer A, Kuss AW, Gilissen C, Fischer A, Schulte-Merker S, Felbor U. (2016) FAM222B is not a likely novel candidate gene for cerebral cavernous malformations. Mol Syndrom. Jul;7(3):144-52.
2015
Herberich SE*, Klose R*, Moll I, Yang W-J, Wüstehube-Lausch J, Fischer A (2015) ANKS1B interacts with the cerebral cavernous malformation protein-1 and controls endothelial permeability but not sprouting angiogenesis. PLoS One.10(12):e0145304.
Yang W-J*, Hu J*, Uemura A, Tetzlaff F, Augustin HG, Fischer A (2015) Semaphorin-3C signals through Neuropilin-1 and PlexinD1 receptors to inhibit pathological angiogenesis. EMBO Mol Med. 7 (10):1267-1284.
Fischer A. Physiologie Band 6, Herz und Kreislauf, 7. Auflage, MEDI-LEARN Verlag, Marburg.
Klose R*, Berger C*, Moll I, Adam MG, Schwarz F, Mohr K, Augustin HG, Fischer A (2015) Soluble Notch ligand and receptor peptides act antagonistically during angiogenesis. Cardiovasc Res. 107(1):153-163.
Wöltje K*, Jabs M*, Fischer A (2015) Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells. PLoS One. 10 (3): e0120547.
Schulz GB, Wieland E, Wüstehube-Lausch J, Boulday G, Moll I, Tournier-Lasserve E, Fischer A (2015) Cerebral cavernous malformation-1 protein controls DLL4-Notch3 signaling between the endothelium and pericytes. Stroke. 46(5):1337-1343.
2013
Adam MG, Berger C, Feldner A, Yang W-J, Wüstehube-Lausch J, Herberich SE, Pinder M, Gesierich S, Hammes H-P, Augustin HG, Fischer A (2013) Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis. Circ Res. 113: 1206-1218.
Schaafhausen MK, Yang WJ, Centanin L, Wittbrodt J, Bosserhoff A, Fischer A, Schartl M, Meierjohann S (2013) Tumor angiogenesis is caused by single melanoma cells in a reactive oxygen species and NF-κB dependent manner. J Cell Sci. 126: 3862-3872.
Fischer A, Zalvide J, Faurobert E, Albiges-Rizo C, Tournier-Lasserve E (2013) Cerebral cavernous malformations: from CCM genes to endothelial cell homeostasis. Trends Mol Med 19 (13): 302-308.
2012
Liebler SS, Feldner A, Adam MG, Korff T, Augustin HG, Fischer A (2012) No evidence for a functional role of bi-directional Notch signaling during angiogenesis. PLoS One. 7 (12): e53074.
group members are underlined
*, equal contribution