Research in the Division Molecular Genome Analysis

Research in the division is centered on the communication of tumor cells within their (micro-) milieu. Tumor-stroma interactions drive tumorigenesis and progression, drug resistance and metastasis. This crosstalk is via signaling between tumor cells and other cells in the tumor microenvironment as well as via intracellular wiring in response to remote cues, e.g., ligands and drugs:

The tumor stroma is comprised of a number of interacting cell types. Several projects in the division focus on the interplay between tumor cells and cell types in Tumor microenvironment. -> Tumor-Stroma Interactions

Alterations in cellular signaling are major drivers of tumor diseases, including breast cancer. We explore the molecular events that are induced by targeted therapeutic drugs in the context of immediate responses as well as during resistance acquisition. -> Cellular Signaling

Genomic alterations in cancer genomes are the initial drivers of disease. We unravel such driver events particularly in less-studied tumor entities, and identify diagnostic and/or prognostic markers. -> Cancer Genomics & Proteomics

Molecular cancer research is driven also by advancements in technologies and tools. We have established reverse phase protein microarrays (RPPA) as a reliable and cost-effective experimental platform for quantitative protein profiling, and apply this in the tumor topics of the division and in collaborations. Furthermore, the division has been a driving force in national and international projects aimed at generating and providing tools to the scientific community. -> Tools & Technologies



For many years, the division had major projects focusing on the molecular pathology of autism spectrum disorders and technologies and their application towards deciphering the human genome, respectively:

The genetics of Autism Spectrum disorders is investigated as a prototype for polygenetic disorders, where we identify and functionally characterize candidate genes and proteins.

The division had worked for a long time on the human chromosomal region Xq28 to develop and test technologies for the systematic genomic and functional analysis of the human genome. The mapping and transcript identification methods contributed essentially to the identification of a number of disease genes and to the sequencing of the human genome.




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