Division of Radiology

Prof. Dr. med. Dipl.-Phys. Heinz-Peter Schlemmer

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The Division of Radiology is developing imaging methods for early detection of cancer and for characterizing its functional and biologic features, using ultrasound, dual-energy CT, PET/MR, PET/CT and ultra-high field MRI . Clinical studies are performed in close cooperation with clinics and institutes of Heidelberg University Hospital and the National Center for Tumor Diseases (NCT) Heidelberg, where the Division newly installed an MRI suite with two scanners in 2015. Furthermore, the Division is a partner of the German Consortium for Translational Oncology (DKTK) and the German Center for Lung Research. Scientific fields of application include early detection and characterization of prostate, lung or breast cancer, and multiple myeloma. In a prospective trial, diffusion-weighted MRI for recalled breast cancer screening patients would help to significantly improve specificity of the workup chain without sacrificing its sensitivity. A cohort study supported by the Jose Carreras Foundation for evaluating prognostic significance of perfusion data from dynamic MRI has been concluded and published. In addition, tools for quantifying individual therapy responses are developed and applied. Further activities include computer-aided image handling for implementation of the complex image information in patient care, e.g. for improving radiotherapy. A clinical Phase I study with MR-guided intra-urethral thermotherapy using high-intensity focused ultrasound is to be followed by a phase II study. A simultaneous PET/MR system is in full operation and being used to improve tumor characterization, individualized therapy planning and therapy monitoring.

FUTURE OUTLOOK:
Our goal is to advance individualized diagnostics and therapy, and image-guided therapy. Ultra-high field MRI is currently applied to advanced imaging of brain tumors. Novel contrast media (CEST agents) will be developed. In a biopsy-controlled study funded by the International Myeloma Foundation, imaging and genetic sequencing are being correlated to assess genetic heterogeneity in multiple myeloma. In patients with bronchogenic carcinoma, novel approaches are being developed for metabolic MRI, 4D-CT imaging and PET with new radiotracers. The CT-based “lung cancer screening and intervention trial” (LUSI study) for early detection of bronchogenic carcinoma is now in its follow-up phase. Novel tools are being developed to quantify therapy responses, e.g. dual-energy CT for assessing changes in tissue composition.

Contact

Prof. Dr. med. Dipl.-Phys. Heinz-Peter Schlemmer
Radiology (E010)
Deutsches Krebsforschungszentrum
Im Neuenheimer Feld 280
69120 Heidelberg
Tel: +49 6221 42 2563

Selected Publications

  • Paech, D., Schuenke, P., Koehler, C., Windschuh, J., Mundiyanapurath, S., Bickelhaupt, S., Bonekamp, D., Bäumer, P., Bachert, P., Ladd, M.E., Bendszus, M., Wick, W., Unterberg, A., Schlemmer, H.-P., Zaiss, M., Radbruch, A: T1-rho-weighted Dynamic Glucose-enhanced MR Imaging in the Human Brain. Radiology. 2017; 162351 [Epub ahead of print].
  • Bickelhaupt S, Laun FB, Tesdorff J, Lederer W, Daniel H, Stieber A, Delorme S, Schlemmer HP. Fast and Noninvasive Characterization of Suspicious Lesions Detected at Breast Cancer X-Ray Screening: Capability of Diffusion-weighted MR Imaging with MIPs. Radiology. 2016; 278(3): 689-97
  • Freitag MT, Radtke JP, Hadaschik BA, Kopp-Schneider A, Eder M, Kopka K, Haberkorn U, Roethke M, Schlemmer HP, Afshar-Oromieh A. Comparison of hybrid (68)Ga-PSMA PET/MRI and (68)Ga-PSMA PET/CT in the evaluation of lymph node and bone metastases of prostate cancer. Eur J Nucl Med Mol Imaging. 2016 Jan;43(1):70-83
  • Radtke JP, Schwab C, Wolf MB, Freitag MT, Alt CD, Kesch C, Popeneciu IV, Huettenbrink C, Gasch C, Klein T, Bonekamp D, Duensing S, Roth W, Schueler S, Stock C, Schlemmer HP, Roethke M, Hohenfellner M, Hadaschik BA. Multiparametric Magnetic Resonance Imaging (MRI) and MRI-Transrectal Ultrasound Fusion Biopsy for Index Tumor Detection: Correlation with Radical Prostatectomy Specimen. Eur Urol. 2016 Jan 19.
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