Mammalian Cell Cycle Control Mechanisms

Research Group Mammalian Cell Cycle Control Mechanisms

Prof. Dr. Ingrid Hoffmann

Multipolar mitotic spindle
© dkfz.de

Initiation and propagation of cancer is not possible without cell division (mitosis) which depends on small cellular organelles known as centrosomes. Similar to DNA replication, the centrosome is duplicated only once within a normal cell cycle. Having the correct number of centrosomes is crucial for proper chromosome segregation during cell division and for the prevention of genomic instability, a hallmark of many cancer cells. Failure to properly duplicate centrosomes results in supernumerary centrosomes, which are frequently found in tumors. The research group Cell Cycle Control and Carcinogenesis is studying the molecular mechanisms underlying centrosome duplication. The aim is to identify and characterize proteins that regulate this process. Our focus is placed on the key regulator of centriole duplication, the polo-like kinase Plk4.

Other projects in the lab are aimed at (1) understanding how misorientation of the mitotic spindle contributes to cancer development (2) unraveling the mechanisms of drug resistance that imposes a major problem in cancer therapy.

Contact

Prof. Dr. Ingrid Hoffmann
Mammalian Cell Cycle Control Mechanisms (F045)
Deutsches Krebsforschungszentrum
Im Neuenheimer Feld 242
69120 Heidelberg
Tel: +49 6221 42 4909

Selected Publications

  • Cizmecioglu, O., Arnold, M., Bahtz, R., Settele, F., Ehret, L., Haselmann-Weiß, U., Antony, C. & Hoffmann, I. (2010). Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome. J Cell Biol. 191, 731-739.
  • Bahtz, R., Seidler, J., Arnold, M., Haselmann-Weiss, U., Antony, C., Lehmann, W and Hoffmann, I., (2012) GCP6 is a substrate of Plk4 and required for centriole duplication. J Cell Sci. 125, 486-496.
  • Zhu, M., Settele, F., Kotak, S., Sanchez-Pulido, L., Ehret, L., Ponting, C, Gönczy, P. and Hoffmann, I. (2013) MISP is a novel Plk1 substrate required for proper spindle orientation and cell cycle progression. J. Cell Biol. 200, 773-787.
  • Brunk, K., Zhu, M., Bärenz, F., Kratz, AS., Haselmann-Weiss, U., Antony, C. and Hoffmann, I., (2016) Cep78 is a novel centriolar protein involved in Plk4-induced centriole overduplication, J. Cell Sci. 129, 2713-2718.
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